A chronic skin ulcer (CSU) is an injury in the form of a sore on the skin or a mucous membrane. A CSU is defined as a wound lesion that lasts more than four weeks without remarkable healing tendency or as a frequently recurring wound. CSU seriously affects the quality of life of patients and causes immense costs to the healthcare system. Although the prevention and treatment of CSU has improved greatly, CSU still remains a great challenge for modern medicine. According to traditional medicine theories, CSU has various symptoms such as local sores, chronic pain and itching, it is also prone to relapse. Traditional medicine has been used for the prevention and treatment of CSU for many years and it has now expanded and is used worldwide.