Groundwater resources is affected by natural and socio-economic factors such as: extending of agriculture area, deforestation, socioeconomic development, environmental pollution, natural disasters, and climate change that prevent the percolation and infiltration process and quality of groundwater [1]. Nowaday, these factors are rapidly changed combined with the negative impacts of climate change have an direct influence on groundwater resources and an indirect influence on groundwater users [2]. Infact in coastal Center of Vietnam, freshwater storage that can be extracted from shallow aquifer are declined, thus it effect to living, agriculture production, industry, transportation, and construction in urban areas and as well as coastal areas[4]. In both science and practical terms, study on evaluation of declination and adaptation of coastal aquifers to the needs of water supply under climate change-sea level rise scenarios which will help decision makers in planning of water resources allocation and looking for alternative water resources (if needed)[5]. Gio Linh plain in Quang Tri province is in coastal Center areas with a coastlines of 15.5km extends from Cua Viet town to Trung Giang ward. It has two main aquifers are Pleistocene and Holocene aquifer that are abstracted for living and production water usage. However, groudwater resources are declined in recently years. The lacking of water supply and increasing of saltwater intrusion in dry season of 2012-2013 due to the changing of rainfall that affect to the storage of water at main water reservoirs in the province. To identify the science basis for proposed solutions for rational use and protection of groundwater resources is important in progress of subtainable development in the region. Consequently, the disertation of « Study the effects of natural, environment, and socio-economic condition to groundwater resources in Gio Linh, Quang Tri taking into account the impact of climate change and sea level rise » was sellected to study and complete.