Recurrent pregnancy loss (RPL) are a common maternity pathology affects 1-3% pregnancy. RPL is defined as having 3 times more consecutive miscarriages, eliminating cases of ectopic pregnancy, hydartiform mole and fetal biochemical abortion should under 20 weeks. The most common causes and can be cured completely of RPL is antiphospholipid syndrome (APS), the antiphospholipid antibody (aPL) causes thrombose in the placenta vessels, which triggers RPL in the first 3 months, stillbirth, fetal growth retardation or premature, severe preeclampsia and so on.