Mudskipper (Pseudapocryptes elongatus) is a special species of high economic value, are consumed widely in domestic and export value. Mudskipper cultures in the provinces Mekong Delta region, however, in the recent times mudskipper were sick with pathological signs of hemorrhage in the body, at the fin and anal with a high mortality rate and widespread. Most of determination of hemorrhagic disease are bacteria. Streptococcus agalactiae is typical as the causative agent of tilapia (Oreochromis sp.) (Pham Hong Quan et al., 2013), red tilapia (Oreochromis sp.) (Dang Thi Hoang Oanh and Nguyen Thanh Phuong, 2012). S. iniae on seabass (Latex calcarifer) (Tran Vi hich and Nguyen Huu Dung, 2011),