In recent years, pollution by chemicals including difficultlydecomposed organic substances (POPs) increasingly created by human beings, causing a lot of implications for human health and the environment. In such developing countries as Vietnam, the use and discharge of chemical waste in agriculture, medicine, industry and other manufacturing sectors without ability to be controlled has caused serious consequences to the environment and humans. In addition, herbicides containing dioxin in existence by the wars after more than 40 years and the nature of dioxins formed during the process of industrial development still continues to cause more serious consequences for the ecological environment and people in Vietnam. Vietnam is a tropical country of biodiversity in the top 10 of the world, especially microbial diversity. There are many species of microorganisms with differently-synthesized enzymes; two of which are oxidoreductive and peroxidase enzyme having included many high performance applications in the fields of economy and protecting human health. Being not only high-activity laccase but also capable of strong activity, just together with liberal oxygen as well as the help of fastening substance or fastening systems (mediator). Then this laccase has been in the greater consideration than any other.